Blar i forfatter "Gundersen, Mona Dixon"

Viser treff 1-9 av 9

    • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

      Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
      <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...

    • Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer 

      Guanglin, Cui; Qi, Haili; Gundersen, Mona Dixon; Yang, Hang; Christiansen, Ingrid B; Sørbye, Sveinung Wergeland; Goll, Rasmus; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-10-17)
      Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence ...

    • Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Fenton, Christopher Graham; Anderssen, Endre; Sørbye, Sveinung Wergeland; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      <i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ...

    • Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis 

      Gundersen, Mona Dixon; Larsen, Kenneth Bowitz; Johnsen, Kay-Martin; Goll, Rasmus; Florholmen, Jon; Haraldsen, Guttorm (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ...

    • Interleukin 33: a locally induced alarmin in the colonic mucosa of ulcerative colitis 

      Gundersen, Mona Dixon (Doctoral thesis; Doktorgradsavhandling, 2022-09-27)
      Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving the mucosal lining of the large bowel (colon and rectum). Common symptoms include bouts of diarrhoea, rectal bleeding and abdominal pain. The pathogenesis of UC is complex and multifactorial. This thesis investigated interleukin 33 (IL-33), an alarmin of the innate immune system. IL-33 is of interest as it is found to be ...

    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...

    • Mucosal gene transcription of ulcerative colitis in endoscopic remission 

      Arkteg, Christian Børde; Goll, Rasmus; Gundersen, Mona Dixon; Anderssen, Endre; Fenton, Christopher Graham; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
      <i>Aim/Objective</i>: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. In UC, a wide range of criteria are used for disease remission, with few studies investigating the differences between disease remission and normal control groups. This paper compares known inflammatory and healing mediators in the mucosa of UC in clinical remission and normal controls, in order to better describe ...

    • Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease 

      Goll, Rasmus; Moe, Øystein Kittel; Johnsen, Kay-Martin; Meyer, Renate Weenås; Friestad, Joachim; Gundersen, Mona Dixon; Kileng, Hege; Johnsen, Knut; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Background and aims - Biological therapy for inflammatory bowel disease is efficient in many cases but not all. The underlying molecular mechanisms behind non-response to biological therapy in inflammatory bowel disease are poorly described. Therefore, we aimed to characterize the mucosal cytokine transcript profile in non-immunogenic, non-responder patients with adequate trough level.<p> <p>Material ...

    • Prediction of long-term remission in patients following discontinuation of anti-TNF therapy in ulcerative colitis: a 10 year follow up study 

      Johnsen, Kay-Martin; Florholmen, Jon; Moe, Øystein Kittel; Gundersen, Mona Dixon; Beilfuss, Julia; Kileng, Hege; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-16)
      Background - The long-term outcomes of Ulcerative colitis (UC) after discontinuation of biological therapy are largely unknown. There is also a lack of accurate and validated markers that can predict outcome after withdrawal accurately. The aims of this study were to describe the long-term outcomes in UC patients following cessation of anti-TNF therapy and explore potential biomarkers as an approach ...